Evaluation of anxiolytic activity of compound Valeriana jatamansi Jones in mice
| Autor: | Jie-Shu You, Yong Liu, Jian-You Guo, Min Peng, Bao-Sheng Zhao, Jin-Li Shi, Huzhan Zheng |
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| Rok vydání: | 2012 |
| Předmět: |
Valerian
Flumazenil Male Light Compound Valeriana jatamansi Jones Elevated maze-plus Pharmacology Anxiety law.invention Mice law Light���dark box Mice Inbred ICR biology Behavior Animal GABAA receptor Ziziphus lcsh:Other systems of medicine General Medicine medicine.symptom medicine.drug Research Article Anxiolytic medicine.drug_class Albizzia Motor Activity Magnoliopsida medicine Animals GABA Modulators Maze Learning Benzodiazepine business.industry Benzodiazepine receptors lcsh:RZ201-999 biology.organism_classification Receptors GABA-A Mechanism of action Complementary and alternative medicine Anti-Anxiety Agents Light–dark box business Phytotherapy Diazepam Drugs Chinese Herbal |
| Zdroj: | BMC Complementary and Alternative Medicine BMC Complementary and Alternative Medicine, Vol 12, Iss 1, p 223 (2012) |
| ISSN: | 1472-6882 |
| Popis: | Background Compound Valeriana jatamansi Jones is a formula for treating anxiety-related diseases in the clinic, which is composed of Valeriana jatamansi Rhizoma et Radix, Ziziphi Spinosae Semen, Albiziae Cortex and Junci Medulla. The purpose of this study was to explore the anxiolytic properties of this compound in mice. Methods Male ICR mice were treated with compound Valerianae Jatamansi Jones (1.2 g/kg, 2.4 g/kg, 4.8 g/kg), saline, diazepam (2 mg/kg) orally for 10 days and then exposed to elevated maze-plus (EPM) and light–dark box (LDB). The effects of the compound on spontaneous activity were evaluated by locomotor activity test. We further investigated the mechanism of action underlying the anxiolytic-like effect of compound by pre-treating animals with antagonists of benzodiazepine (flumazenil, 3mg/kg) prior to evaluation using EPM and LDB. Results Compound Valerianae Jatamansi Jones (2.4, 4.8 g/kg, p.o.) significantly increased entries (PPPPP>0.05). In addition, compound Valerianae Jatamansi Jones treatment didn’t affect the spontaneous activity in mice (P> 0.05). Conclusions The present study supports the hypothesis that compound Valeriana jatamansi Jones exert anxiolytic action but no sedative effects in mice and that this effect might be mediated by benzodiazepine receptors. |
| Databáze: | OpenAIRE |
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