Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration
| Autor: | Ashley R. Bonneau, Kutay Deniz Atabay, M. Lucila Scimone, Christopher T. Fincher, Peter W. Reddien, Dayan J. Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
genetic structures
Population Eye transplantation Eye Article Schmidtea mediterranea medicine Animals Regeneration Myocyte Axon education Ocular Physiological Phenomena Process (anatomy) Neurons education.field_of_study Multidisciplinary biology Muscles Regeneration (biology) Planarians biology.organism_classification Axons Nerve Regeneration medicine.anatomical_structure Planarian Photoreceptor Cells Invertebrate Neuroscience |
| Zdroj: | PMC Science |
| Popis: | Guiding regeneration Many adult organisms can regenerate neural circuits after injury. However, it is not clear which guidance mechanisms operate to promote axon path finding in the adult. Scimone et al. addressed this question by investigating regeneration of the planarian visual system (see the Perspective by Roberts-Galbraith). Distinct muscle cell populations were found in close association with photoreceptor axons that, together with a neuron class, facilitated visual system assembly after diverse injuries or eye transplantations. These cells exhibited features similar to embryonic guidepost cells and were specified independently of eyes in precise locations by the action of adult positional information cues. Absence of these guidepost-like cells was associated with defective neuronal wiring in regeneration. Science , this issue p. eaba3203 ; see also p. 1428 |
| Databáze: | OpenAIRE |
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