Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood
| Autor: | Susan J. Fisher, Alexandra P. Hess, Christian Heiss, A. Schanz, Marion Blumenstein, Michael T. McMaster, Robyn A. North, Virginia D. Winn, J.S. Kruessel |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Receptors CXCR4 medicine.medical_specialty Placenta Syncytiotrophoblasts Pregnancy Proteins Preeclampsia Pathogenesis Young Adult Syncytiotrophoblast Pre-Eclampsia Pregnancy Internal medicine medicine Humans Prospective Studies Angiogenic Proteins reproductive and urinary physiology CXCL16 Receptors CXCR6 Receptors Scavenger Eclampsia business.industry Obstetrics and Gynecology Chemokine CXCL16 medicine.disease Chemokine CXCL12 biological factors female genital diseases and pregnancy complications Trophoblasts Endocrinology medicine.anatomical_structure Reproductive Medicine Case-Control Studies embryonic structures Receptors Virus Gestation Female Receptors Chemokine biological phenomena cell phenomena and immunity business Chemokines CXC |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 157:32-37 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2011.02.023 |
| Popis: | Objectives Placental derived vasculogenic/angiogenic substances in maternal blood are dysregulated in pre-eclampsia. We hypothesized that CXCL12, a chemokine with vasculogenic actions, is amongst such molecules. Study design CXCL12, CXCL16, CXCR4, and CXCR6 immunolocalization in placental tissue was analyzed in pre-eclampsia (n = 8) in comparison to controls (n = 8). CXCL12, measured by ELISA in blood, in women diagnosed with pre-eclampsia (n = 14) and prior to the development of pre-eclampsia (at 20 weeks’ gestation, n = 20) was compared with CXCL12 concentrations in gestation-matched, healthy control subjects (n = 34). Results In placental tissue, syncytiotrophoblast staining for CXCL12 was increased in pre-eclampsia. Maternal serum CXCL12 was increased in pre-eclampsia [2000 (SD 402) vs 1484 (SD 261) pg/ml, P = 0.01] but not in plasma obtained at 20 weeks of gestation prior to the onset of pre-eclampsia [1183 (SD 336) vs 1036 (SD 144) pg/ml, P = 0.09]. Conclusion Our data suggest that the syncytiotrophoblast contributes to a pre-eclampsia-associated increase in CXCL12 levels in maternal blood. These findings support the hypothesis that an imbalance of angiogenic factors contributes to the pathogenesis of pre-eclampsia. |
| Databáze: | OpenAIRE |
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