Time to relief of episodic symptoms of gastro-oesophageal reflux disease. A crossover comparison of single doses of the effervescent and standard formulations of ranitidine
| Autor: | G. Dahl, K. Andrén, P. Hellke, M. Elm, A.-L. Nyth |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Cross-Over Studies Esophageal disease business.industry Gastroenterology Reflux Diary card medicine.disease Anti-Ulcer Agents Ranitidine Crossover study Patient satisfaction Treatment Outcome Symptom relief Gastro Patient Satisfaction Internal medicine medicine Gastroesophageal Reflux Humans business medicine.drug |
| Zdroj: | Scandinavian journal of gastroenterology. 33(9) |
| ISSN: | 0036-5521 |
| Popis: | The length of time until symptom relief and the consistency of response are important aspects of the management of episodes of gastro-oesophageal reflux disease (GORD).In an open, randomized, crossover study 98 patients treated 3 episodes of GORD with ranitidine effervescent formulation and 3 with ranitidine standard formulation. The patients filled in a diary card during the 1st h after each study medication. Satisfaction with the formulations and the formulation of choice were determined at the end of the study.A higher percentage of episodes with acceptable symptom relief (82.4% versus 73.1% P=0.024) and a shorter time to acceptable symptom relief (27 min versus 36 min; P0.001) were achieved with the effervescent formulation. Sixty-five per cent preferred the effervescent formulation (P0.01).An increased consistency of response and a more rapid symptom relief were achieved with treatment with the ranitidine effervescent formulation, indicating it may be more appropriate for on-demand treatment in patients with episodes of GORD. |
| Databáze: | OpenAIRE |
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