The role of estrogens in the adipose tissue milieu
| Autor: | Victoria J. Vieira-Potter, Deborah J. Clegg, Orhan K. Öz, John R. Bracht, Roberta de Souza Santos, Biff F. Palmer |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Adipose tissue 030209 endocrinology & metabolism Type 2 diabetes Standard measure Body weight General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine History and Philosophy of Science Internal medicine Adipocytes medicine Animals Humans Gonadal Steroid Hormones business.industry General Neuroscience Estrogens medicine.disease Obesity MicroRNAs 030104 developmental biology Endocrinology Adipose Tissue Menopause business Body mass index Dyslipidemia Hormone |
| Zdroj: | Annals of the New York Academy of Sciences. 1461:127-143 |
| ISSN: | 1749-6632 0077-8923 |
| Popis: | One of the leading causes for the development of adverse metabolic effects, including type 2 diabetes, dyslipidemia, and cardiovascular diseases, is the accumulation of excess body weight, often measured by body mass index (BMI). Although BMI, calculated using weight and height, is the standard measure used to determine body adiposity in clinical and public health guidelines, an inherent limitation is that BMI does not distinguish where in the body adiposity is deposited. Central obesity, characterized by greater accumulation of adiposity in the abdominal region, has been associated with a higher risk of mortality, independent of BMI. Importantly, one of the determinants of body fat distribution is sex hormones. Both estrogens and androgens appear to directly and indirectly influence body fat distribution. Our review will focus specifically on the role of estrogens and their influence in determining body fat distribution and overall health of adipose tissues, and the role of epigenetic mechanisms in regulating the production and function of estrogens. |
| Databáze: | OpenAIRE |
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