Triphenylamine-appended cyclometallated iridium(III) complexes: Preparation, photophysical properties and application in biology/luminescence imaging
| Autor: | Yifei Liu, Yan Wang, Laijin Tian, Haojie Wang, Hailong Hao, Zhe Liu, Xiangdong He, Xingxing Ge, Xicheng Liu, Mingxiao Shao, Zhihong Jing |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Luminescence
Serum albumin chemistry.chemical_element Antineoplastic Agents Apoptosis Microbial Sensitivity Tests Iridium 010402 general chemistry Triphenylamine 01 natural sciences Biochemistry Inorganic Chemistry Structure-Activity Relationship Bipyridine chemistry.chemical_compound Coordination Complexes Escherichia coli Animals Humans Cell Proliferation Membrane Potential Mitochondrial Aniline Compounds Quenching (fluorescence) biology 010405 organic chemistry Cell Cycle Serum Albumin Bovine Cell Cycle Checkpoints Combinatorial chemistry Fluorescence Anti-Bacterial Agents 0104 chemical sciences chemistry A549 Cells Lipophilicity Cancer cell biology.protein Cattle Drug Screening Assays Antitumor Lysosomes |
| Zdroj: | Journal of Inorganic Biochemistry. 199:110757 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/j.jinorgbio.2019.110757 |
| Popis: | Four triphenylamine (TPA)-appended cyclometallated iridium(III) complexes were designed and synthesized. Photophysical properties of these complexes were studied, and density functional theory (DFT) was utilized to analyze the influence of the ancillary ligands (TPA-modified bipyridine) to these complexes. The introduction of TPA units could effectively adjust the lipid solubility of complexes (logP), and endowed complexes with potential bioactivity (anticancer, antibacterial and bactericidal activity), especially in the field of anticancer (the best value of IC50 is 4.34±0.01μM). Interestingly, complexe 4 show some selectivity for cancer cells versus normal cells. Meanwhile, complexes could effectively prevent the metastasis of cancer cells. Complexes can be transported by serum albumin and followed by the static quenching mechanism (Kq: 1013M-1s-1), disturb cell cycle at G0/G1 phase, and induce apoptosis. The favorable fluorescence property confirmed these complexes followed by an energy-dependent cellular uptake mechanism, effectively accumulated in lysosomes (PCC: >0.95) and induced lysosomal damage, and eventually leaded to cell death. Our study demonstrates that these complexes are potential anticancer agents with dual functions, including metastasis inhibition and lysosomal damage. |
| Databáze: | OpenAIRE |
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