A comparative clinical trial of adriamycin and 5-fluorouracil in advanced prostatic cancer: Prognostic factors and response
| Autor: | Janardan D. Khandekar, William D. Dewys, Colin B. Begg, Creech R, Harvey S. Brodovsky |
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| Rok vydání: | 1983 |
| Předmět: |
Male
Oncology medicine.medical_specialty Urology medicine.medical_treatment Acid Phosphatase Adenocarcinoma law.invention Randomized controlled trial law Prostate Internal medicine medicine Humans Clinical Trials as Topic Chemotherapy business.industry Prostatic Neoplasms Cancer Prognosis medicine.disease Clinical trial medicine.anatomical_structure Doxorubicin Fluorouracil Hormone therapy business medicine.drug |
| Zdroj: | The Prostate. 4:1-11 |
| ISSN: | 1097-0045 0270-4137 |
| Popis: | In patients with metastatic hormone-relapsed adenocarcinoma of the prostate, adriamycin was compared to 5-fluorouracil in a randomized trial in 99 patients and adriamycin alone was studied in an open trial in 48 patients. Response to adriamycin was superior as judged by response of measurable disease (25 vs 8%; P less than 0.05) and survival (median 29 vs 24 weeks; Cox analysis, P less than 0.03), but comparable as judged by acid phosphatase response. Ambulatory status and site of metastases influenced rate of response to chemotherapy. Activity level, site of metastases, weight loss, and the symptom of protein aversion were prognostic factors for survival. Hematologic and gastrointestinal toxicity were frequent but were tolerated satisfactorily. Adriamycin therapy may be beneficial in patients with prostatic cancer after hormone therapy. |
| Databáze: | OpenAIRE |
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