Diagnosis and prevention of the vasodepressor type of neurally mediated syncope in Japanese patients

Autor: Koichiro Yoshioka, Susumu Sakama, Tetsuri Sakai, Mari Amino, Tomoyoshi Komiyama, Kyong Hee Lee, Kengo Ayabe, Eiichiro Nagata, Misaki Hasegawa, Ayumi Sasaki, Yuji Ikari, Atsuhiko Yagishita, Masahiro Morise, Hiroyuki Kobayashi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Blood Pressure
Vascular Medicine
Biochemistry
Cardiovascular System
Electrocardiography
White Blood Cells
Heart Rate
Animal Cells
Tilt-Table Test
Medicine and Health Sciences
Syncope
Vasovagal
heterocyclic compounds
Lymphocytes
Multidisciplinary
medicine.diagnostic_test
Pulse (signal processing)
Enzymes
Bioassays and Physiological Analysis
Circulatory system
Cardiology
Medicine
Female
medicine.symptom
Anatomy
Cellular Types
Adenylyl Cyclase
Arrhythmia
Research Article
Adult
medicine.medical_specialty
Science
Immune Cells
Immunology
Lyases
Fainting
Research and Analysis Methods
Syncope
Signs and Symptoms
Asian People
Internal medicine
Heart rate
medicine
Humans
Autonomic nerve
Blood Cells
business.industry
Electrophysiological Techniques
Biology and Life Sciences
Proteins
Cell Biology
Blood pressure
Enzymology
Cardiovascular Anatomy
Electrocardiography
Ambulatory
Blood Vessels
Cardiac Electrophysiology
Clinical Medicine
business
Cyclase activity
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0251450 (2021)
ISSN: 1932-6203
Popis: We investigated circulatory dynamics in patients with vasodepressor type neurally mediated syncope (VT-NMS) by performing high-resolution Holter electrocardiography and a correlation analysis of changes in adenylate cyclase activity, blood pressure, and pulse during the head-up tilt test. Holter electrocardiography was performed for 30 patients. Adenylate cyclase activity was evaluated in lymphocytes from blood samples taken at rest and during the head-up tilt test. There was no change in autonomic nerve fluctuation during electrocardiography in VT-NMS patients, but our results showed a significant difference in blood pressure and adenylate cyclase activity between VT-NMS patients and healthy volunteers; the systolic blood pressure of VT-NMS patients decreased after 5 min, while at 10 min, the adenylate cyclase activity was the highest (0.53%) and the systolic blood pressure was the lowest (111.8 mm Hg). Pulse rates increased after 10 min. VT-NMS patients showed higher blood pressure, pulse rate, and adenylate cyclase activity during the tilt test than did healthy volunteers. In patients with syncope, standing for longer than 10 minutes may increase the risk of VT-NMS. From our results, we consider it likely that high systolic blood pressure and adenylate cyclase activity at rest cause fainting in VT-NMS patients. Our findings may be helpful for identifying individuals with a high risk of developing NMS in the healthy population.
Databáze: OpenAIRE
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