Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis
| Autor: | Xu-Fan Wang, Rui-Xue Leng, Zong-Wen Shuai, Linlin Zhang, Dongsheng Di, Xiaoxiao Wu, Qian Huang, Rui-Shan Liu, Dong-Qing Ye |
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| Rok vydání: | 2021 |
| Předmět: |
rheumatoid arthritis
Genotype medicine.medical_treatment Single-nucleotide polymorphism 030204 cardiovascular system & hematology Biology Polymorphism Single Nucleotide susceptibility Arthritis Rheumatoid single nucleotide polymorphisms 03 medical and health sciences 0302 clinical medicine Rheumatology cytokine medicine Humans Genetic Predisposition to Disease 030212 general & internal medicine Gene Genetics Tumor Necrosis Factor-alpha Genetic variants General Medicine medicine.disease MicroRNAs Cytokine Case-Control Studies Rheumatoid arthritis MiR-146a Microrna 146a Research Article Genome-Wide Association Study |
| Zdroj: | Annals of Medicine article-version (VoR) Version of Record |
| ISSN: | 1365-2060 0785-3890 |
| Popis: | To investigated the association between single nucleotide polymorphisms (SNPs) in microRNA-146a (miR-146a) gene and susceptibility of rheumatoid arthritis (RA). We systemically extracted the genetic data of miR-146a from previous genome-wide association studies (GWASs) of RA. Subsequently, we performed a replication study in an independent Chinese cohort for selected variant. A meta-analysis combined the previous GWASs with the replication study was also conducted. The epigenetic annotation and cytokine assay were used for exploring potential variant function. The extracted genetic association data from three previous GWASs showed that the allele T of functional SNP rs2431697 increased RA susceptibility. The significant association for the SNP was also found in the Chinese replication cohort (OR = 1.24, 95% CI = 1.06–1.46, p = 8.69E-03). The estimated effect size for this SNP was larger in Asian population than that in European population (Asian meta-analysis: OR = 1.15, 95% CI = 1.09–1.22, p = 4.37E-07; Tran-ethnic meta-analysis: OR = 1.07, 95% CI = 1.04–1.10, p = 1.79E-06). The cytokine assay also showed that the risk allele T of the SNP rs2431697 is inversely associated with plasma TNF-α levels in health controls (p = .016). In summary, this study supports that genetic variant in miR-146a gene is associated with RA risk.KEY MESSAGESThe association between SNPs in miR-146a gene and susceptibility of RA was unclear.We investigated the genetic association using GWASs data and a replication study.The SNP rs2431697 in miR-146a gene is associated with RA risk. The association between SNPs in miR-146a gene and susceptibility of RA was unclear. We investigated the genetic association using GWASs data and a replication study. The SNP rs2431697 in miR-146a gene is associated with RA risk. |
| Databáze: | OpenAIRE |
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