Increased Lung Uptake of Technetium-99m Hexamethylpropylene Amine Oxime in Systemic Lupus erythematosus
| Autor: | J.J. Wang, Chuen Ming Shih, Albert Kao, S.-T. Ho, Y.-C. Shiau |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine medicine.medical_specialty Systemic disease Pathology Gastroenterology Technetium Tc 99m Exametazime immune system diseases Internal medicine medicine Humans Lupus Erythematosus Systemic Radionuclide Imaging skin and connective tissue diseases Lung Stroke Lupus erythematosus business.industry Respiratory disease Middle Aged medicine.disease Connective tissue disease Respiratory Function Tests medicine.anatomical_structure Liver Female Endothelium Vascular Radiopharmaceuticals Complication business Technetium-99m |
| Zdroj: | Respiration. 69:143-147 |
| ISSN: | 1423-0356 0025-7931 |
| DOI: | 10.1159/000056317 |
| Popis: | Background: Systemic lupus erythematosus (SLE) can affect every organ. Involvement of the lungs in this disease is a significant cause of morbidity and mortality. Objectives: To assess pulmonary vascular endothelium damage in SLE by lung uptake of technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO). Methods: Lung uptake of 99mTc-HMPAO was measured in 20 SLE patients and for comparison in 25 controls without SLE, referred for brain imaging due to dementia or stroke. Of the 20 SLE patients, 10 had significant clinical pulmonary manifestations. However, all SLE patients had normal chest X-ray findings. Anterior lung image, including a large part of the liver, was taken 10 min after intravenous injection of 20–25 mCi of 99mTc-HMPAO. Regions of interest were calculated over the liver and lung. Results: The mean lung/liver uptake ratio in patients without SLE was 0.36 ± 0.1. The mean lung/liver uptake ratio in SLE patients was 0.79 ± 0.58. The difference was significant. Conclusions: Our results indicated that determining the ratio of lung/liver uptake of 99mTc-HMPAO may be a useful complementary method to assess pulmonary injury in SLE patients. |
| Databáze: | OpenAIRE |
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