Oral contraceptive use and fracture risk around the menopausal transition
| Autor: | Leslie Spangler, Andrea Z. LaCroix, Nancy Gell, Laura Ichikawa, Rebecca A. Hubbard, Delia Scholes, Belinda H. Operskalski, Susan M. Ott |
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| Rok vydání: | 2016 |
| Předmět: |
Aging
Osteoporosis Logistic regression Medical and Health Sciences Fractures Bone 0302 clinical medicine Risk Factors Odds Ratio Electronic Health Records 030212 general & internal medicine education.field_of_study 030219 obstetrics & reproductive medicine Obstetrics Obstetrics and Gynecology Contraceptives Middle Aged Menopause Family planning Female Oral medicine.medical_specialty Northwestern United States Population Reproductive Health and Childbirth Article Contraceptives Oral Hormonal 03 medical and health sciences Clinical Research medicine Confidence Intervals Humans Bone Obstetrics & Reproductive Medicine education Gynecology Hormonal business.industry Contraception/Reproduction Prevention Case-control study Odds ratio medicine.disease Estrogen Confidence interval Good Health and Well Being Logistic Models Premenopause Case-Control Studies business Fractures |
| Zdroj: | Menopause (New York, N.Y.), vol 23, iss 2 Scholes, Delia; LaCroix, Andrea Z; Hubbard, Rebecca A; Ichikawa, Laura E; Spangler, Leslie; Operskalski, Belinda H; et al.(2016). Oral contraceptive use and fracture risk around the menopausal transition. Menopause, 23(2), 166-174. doi: 10.1097/gme.0000000000000595. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/62d1293x |
| ISSN: | 1530-0374 |
| DOI: | 10.1097/gme.0000000000000595. |
| Popis: | ObjectiveThe effect of oral contraceptive (OC) use on risk of fracture remains unclear, and use during later reproductive life may be increasing. To determine the association between OC use during later reproductive life and risk of fracture across the menopausal transition, we conducted a population-based case-control study in a Pacific Northwest HMO, Group Health Cooperative.MethodsFor the January 2008 to March 2013 interval, 1,204 case women aged 45 to 59 years with incident fractures, and 2,275 control women were enrolled. Potential cases with fracture codes in automated data were adjudicated by electronic health record review. Potential control women without fracture codes were selected concurrently, sampling based on age. Participants received a structured study interview. Using logistic regression, associations between OC use and fracture risk were calculated as odds ratios (ORs) and 95% confidence intervals (CIs).ResultsParticipation was 69% for cases and 64% for controls. The study sample was 82% white; mean age was 54 years. The most common fracture site for cases was the wrist/forearm (32%). Adjusted fracture risk did not differ between cases versus controls for OC use in the 10 years before menopause (OR 0.90, 95% CI 0.74, 1.11); for OC use after age 38 (OR 0.94, 95% CI 0.78, 1.14); for duration of use, or for other OC exposures.ConclusionsThe current study does not show an association between fractures near the menopausal transition and OC use in the decade before menopause or after age 38. For women considering OC use at these times, fracture risk does not seem to be either reduced or-reassuringly-increased. |
| Databáze: | OpenAIRE |
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