Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma
| Autor: | Peter Radermacher, Timothy R. Billiar, Pietro Ghezzi, Lukas Martin, Christoph Thiemermann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
multiple organ failure Translational Research Biomedical sepsis 0302 clinical medicine Immunology and Allergy Medicine SIRS translational studies Disease Management Pathophysiology animal models Editorial trauma Models Animal Disease Susceptibility medicine.symptom lcsh:Immunologic diseases. Allergy medicine.medical_specialty Immunology Kontrollierte klinische Studie Inflammation Trauma Sepsis Clinical trials as topic 03 medical and health sciences Animals Humans ddc:610 Elective surgery Intensive care medicine Tiermodell clinical trials business.industry Wounds and injuries Organ dysfunction Multiple trauma medicine.disease Multiple organ failure Clinical trial Disease Models Animal 030104 developmental biology Organversagen Pancreatitis Wounds and Injuries business lcsh:RC581-607 DDC 610 / Medicine & health 030215 immunology Large animal |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| ISSN: | 1664-3224 |
| Popis: | Multiple organ dysfunction or even failure after sepsis or trauma is due to a dysregulated host response. Currently, besides (surgical) source control (e.g., control of bleeding or drainage of abscesses) and administration of antimicrobial drugs, therapeutic approaches are limited to supportive care. Advances in our understanding of the key pathophysiological pathways involved in the excessive inflammation triggered by trauma, sepsis and/or ischemia-reperfusion have had limited impact. The 28 article in this Research Topic focus on the molecular mechanisms behind (hyper) inflammation after sepsis or trauma, with special emphasis on preclinical and translational studies that target potential organ-protective and/or -resuscitative therapeutic strategies. Most studies report rodent models of trauma and elective surgery (three articles), non-microbial hyper-inflammation induced with endotoxin exposure (LPS; seven articles) and chemical pancreatitis (one article), and cecal ligation and puncture-induced sepsis (six articles). Additional papers summarize investigations of human material (six articles) or fully-resuscitated large animal models (two articles). These article are complimented by four reviews and a commentary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|