Reversible pH-Responsive Behavior of Ruthenium(II) Arene Complexes with Tethered Carboxylate
| Autor: | Sonia Infante-Tadeo, Ana M. Pizarro, Francisco Martínez-Peña, Abraha Habtemariam |
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| Rok vydání: | 2018 |
| Předmět: |
Models
Molecular Cell Survival Phenanthroline Carboxylic Acids Aquation chemistry.chemical_element Antineoplastic Agents Ethylenediamine Crystallography X-Ray 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis Ruthenium Adduct Inorganic Chemistry chemistry.chemical_compound Coordination Complexes Cell Line Tumor Humans Formate Carboxylate Physical and Theoretical Chemistry Cell Proliferation 010405 organic chemistry Ligand Hydrogen-Ion Concentration NAD 0104 chemical sciences chemistry Drug Screening Assays Antitumor Oxidation-Reduction |
| Zdroj: | Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia instname |
| ISSN: | 1520-510X 0020-1669 |
| Popis: | Five complexes of formula [Ru(η6-C6H5CH2COOH)(XY)Cl]Cl/Na (XY = ethylenediamine (1), o-phenylenediamine (2), phenanthroline (3), and oxalato (4)) and [Ru(η6:κ1-C6H5CH2COO)(tmen)]Cl (tmen = N, N, N', N'-tetramethylethylenediamine, 5C) have been synthesized and fully characterized. Five new X-ray crystal structures ([Ru(η6-C6H5CH2COOH)(μ-Cl)Cl]2, 1, 3, 4, and 5C·PF6) have been determined, which are the first examples of ruthenium(II) structures with phenylacetic acid as arene ligand. Furthermore, 5C·PF6 is the first example of a five-membered tether ring with a Ru(η6:κ1-arene:O) bond. The tether ring in these complexes opens in acidic pH ( |
| Databáze: | OpenAIRE |
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