Androgen Deficiency: Association With Increased Anxiety and Depression Symptom Severity in Anorexia Nervosa
| Autor: | Karen K. Miller, Anna B. Binstock, David B. Herzog, Erinne Meenaghan, Anne Klibanski, Alicia M. Zha, Elizabeth A. Lawson, Tamara Wexler, Madhusmita Misra |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Anorexia Nervosa Adolescent medicine.medical_treatment Anxiety medicine.disease_cause Anorexia nervosa Severity of Illness Index Predictive Value of Tests mental disorders Androgen deficiency medicine Humans Interpersonal Relations Testosterone Social Behavior Psychiatry Depression Hamilton Rating Scale for Depression Perfectionism (psychology) Middle Aged medicine.disease Eating Disorder Inventory Self Concept Psychiatry and Mental health Distress Cross-Sectional Studies Female Androgen replacement therapy medicine.symptom Psychology Clinical psychology |
| Zdroj: | The Journal of Clinical Psychiatry. 68:959-965 |
| ISSN: | 0160-6689 |
| DOI: | 10.4088/jcp.v68n0621 |
| Popis: | Objective Anorexia nervosa is associated with a high prevalence of psychiatric comorbidities, including anxiety and depression, and with endocrine dysfunction, including relative androgen deficiency compared with healthy young women. Because androgens are known to affect mood and behavior, we hypothesized that low endogenous androgen production in anorexia nervosa would predict anxiety and depression severity. Method Serum androgen levels and severity of depression (Hamilton Rating Scale for Depression) and anxiety (Hamilton Rating Scale for Anxiety) were measured in 43 community-dwelling women with DSM-IV-defined anorexia nervosa from May 2004 to July 2006. Results Strong inverse associations were observed between both total and free testosterone and anxiety and depression severity, independent of weight. Free testosterone was also inversely associated with 4 eating-disordered thinking and behavior subscales of the Eating Disorder Inventory 2 (EDI-2). Mean free testosterone blood levels were lower in women with clinically significant anxiety and in women with clinically significant depression, compared with those without. In stepwise regression models, free testosterone was an important predictor of anxiety and depression severity. EDI-2 ineffectiveness, perfectionism, interpersonal distress, and social insecurity scores were also inversely associated with androgen levels, independent of weight. Conclusions Our data suggest that low androgen levels may contribute to anxiety, depression, and eating-disordered thinking and behavior in women with anorexia nervosa and form the basis for future studies to investigate the effectiveness of androgen replacement therapy. Clinical trials registration ClinicalTrials.gov identifier NCT00089843. |
| Databáze: | OpenAIRE |
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