Maternal obesity and increased risk for autism and developmental delay among very preterm infants
| Autor: | Jeffrey J. Neil, Lauren C. Reynolds, Roberta Pineda, Cynthia E. Rogers, Terrie E. Inder |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Developmental Disabilities body mass index Weight Gain Language Development behavioral disciplines and activities Article Cohort Studies Pregnancy Risk Factors neonatal intensive care mental disorders medicine Humans Obesity Prospective Studies Neonatology Autistic Disorder Prospective cohort study 2. Zero hunger neurodevelopment business.industry Obstetrics Infant Newborn Brain Obstetrics and Gynecology Gestational age medicine.disease Magnetic Resonance Imaging premature infant developmental delay Pregnancy Complications Child Preschool Pediatrics Perinatology and Child Health Autism Female business Body mass index Infant Premature Cohort study |
| Zdroj: | Journal of perinatology : official journal of the California Perinatal Association |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | Objective Thirty-five percent of women of child-bearing age are obese, and there is evidence that maternal obesity may increase the risk for adverse neurodevelopmental outcome. However, research regarding obesity and neurodevelopment among children born preterm is limited. This study aimed to determine associations between maternal obesity and neurodevelopment in very preterm children at age 2 years. Study Design Maternal/infant dyads (n=62) born ≤30 weeks gestation were enrolled in a prospective cohort study at a level-III neonatal intensive care unit. Mothers were classified as obese or non-obese based on pre-pregnancy body mass index. Infants underwent magnetic resonance imaging at term equivalent and developmental testing at age 2. Maternal obesity was investigated for associations with neurodevelopment. Results Maternal obesity was associated with positive screen for autism (OR=9.88, p=0.002) and lower composite language scores (β=-9.36, [CI=-15.11, -3.61], p=0.002). Conclusion Maternal obesity was associated with adverse neurodevelopmental outcome at age 2 in this cohort of very preterm children. This study requires replication, but may support targeted surveillance of infants born to women with maternal obesity. |
| Databáze: | OpenAIRE |
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