Efficacy and safety of continuous antiviral therapy from preconception to prevent perinatal transmission of hepatitis B virus
| Autor: | Fang He, Guanxin Shen, Xueting Ou, Xingfei Pan, Haibin Wang, Zhijian Wang, Huishu Liu, Bin Cao, Guocheng Liu, Shuo Zheng, Dunjin Chen, Shiliang Liu, Zhenyu Huang, Liyang Zhou, Yifen Liu, Jingsi Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Perinatal transmission HBsAg medicine.medical_specialty Hepatitis B virus Offspring Mothers lcsh:Medicine medicine.disease_cause Group A Antiviral Agents Group B Article 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Medicine Humans Prospective Studies Pregnancy Complications Infectious lcsh:Science Preventive medicine Multidisciplinary business.industry lcsh:R Antiviral therapy Infant Newborn Infant medicine.disease Hepatitis B Infectious Disease Transmission Vertical digestive system diseases 030104 developmental biology Treatment Outcome Female lcsh:Q Safety business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-70644-4 |
| Popis: | Few studies were conducted to assess safety and efficacy of continuous antiviral therapy administrated from preconception. In the present study, 136 eligible women with chronic HBV infection were recruited, and assigned to active chronic hepatitis B (CHB) (Group A, B or C) or chronic HBV carrier (Group D). Antiviral therapy was administrated in preconception (Group A), in early (Group B) or late pregnancy (Group C and Group D). Immunoprophylaxis was administrated to all infants. Mothers’ HBV status and ALT were assessed at delivery and 7 months postpartum. Offspring’s HBV status was examined at 7 months old. Group A women showed low HBV DNA level and normal ALT throughout pregnancy. All women at delivery had an HBV DNA level of less than 106 IU/ml, but the proportion of patients with lower HBV DNA level in Group A was higher than any of other three groups (P |
| Databáze: | OpenAIRE |
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