Detection of cocaine and metabolites from mouse femur buried in soil
| Autor: | Kazuhiko Kibayashi, Yuki Tatara, Ken-ichiro Nakao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Burial Ecgonine methyl ester Mice Inbred Strains 01 natural sciences Pathology and Forensic Medicine Soil 03 medical and health sciences 0302 clinical medicine Cocaine Benzoyl ecgonine Tandem Mass Spectrometry Internal medicine Lc ms ms medicine Animals Femur 030216 legal & forensic medicine Biotransformation business.industry 010401 analytical chemistry Forensic Medicine 0104 chemical sciences Issues ethics and legal aspects Endocrinology Drug addict business Chromatography Liquid |
| Zdroj: | Legal Medicine. 37:1-6 |
| ISSN: | 1344-6223 |
| DOI: | 10.1016/j.legalmed.2018.11.005 |
| Popis: | Drug addicts are frequently involved in committing homicides, and burial in the ground is often performed by offenders for body disposal. Therefore, toxicological analyses of buried bones are vitally important for investigating the cause and circumstance of death. Cocaine concentrations in heart blood, femoral muscle, and femur were measured in mice after injections of 5, 15, and 30 mg/kg cocaine and in femurs buried in soil. The concentrations of cocaine in femurs (253.67–1345.31 ng/g) were higher than those found in heart blood (3.14–28.73 ng/mL) and femoral muscle (76.41–429.76 ng/g). The cocaine concentrations in buried femurs (54.83–388.68 ng/g) were significantly lower than those in unburied femurs (253.67–1345.31 ng/g). Further, cocaine was detected in femurs after being buried for 7–180 days in soil. These findings indicate that cocaine concentrations are higher in bone than in heart blood and femoral muscle and that the concentration decreases after burial in soil. |
| Databáze: | OpenAIRE |
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