The Immunohistochemical Expression of Growth Hormone-Releasing Hormone Receptor Splice Variant 1 Is a Favorable Prognostic Marker in Colorectal Cancer
| Autor: | Michael Koutsilieris, Marta Zarandi, Vassilios Komborozos, Elena Theophanous, Jozsef L. Varga, Andrew V. Schally, Andreas Scorilas, George Veloudis, Constantina Petraki |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Receptors Neuropeptide Oncology medicine.medical_specialty Pituitary gland Growth-hormone-releasing hormone receptor Colorectal cancer Kaplan-Meier Estimate Statistics Nonparametric Cohort Studies Axin Protein Receptors Pituitary Hormone-Regulating Hormone Internal medicine Biomarkers Tumor Genetics medicine Humans Protein Isoforms Neoplasm Invasiveness splice Neoplasm Metastasis Receptor Molecular Biology Genetics (clinical) Aged Neoplasm Staging Proportional Hazards Models Aged 80 and over business.industry Middle Aged Cadherins Prognosis medicine.disease Immunohistochemistry Molecular medicine Cytoskeletal Proteins medicine.anatomical_structure Cancer research Molecular Medicine Female Colorectal Neoplasms business Research Article Hormone |
| Zdroj: | Molecular Medicine. 15:242-247 |
| ISSN: | 1528-3658 1076-1551 |
| DOI: | 10.2119/molmed.2008.00132 |
| Popis: | Hypothalamic growth hormone (GH)-releasing hormone (GHRH) regulates the release of GH from the pituitary gland. The receptors for GHRH (GHRH-R) are expressed predominantly in the pituitary. Recent evidence demonstrates that splice variants of the GHRH receptor are also expressed in several nonpituitary tissues, both normal and tumoral, as well as in cancer cell lines. The aim of this study was to investigate the expression of the splice variant 1 (SV-1) of GHRH-R in colorectal cancer (CRC). Seventy patients who underwent partial colectomy for CRC were enrolled in the study. Immunohistochemical expression of SV-1 was studied in paraffin-embedded sections of patient tumor tissue. A cytoplasmic supranuclear expression of SV-1 was observed in CRC as well as in the normal colon mucosa. Tumor grade and pathological stage were negatively correlated with expression of SV-1 (P = 0.012 and P = 0.013, respectively). CRCs metastatic to the liver showed a lower expression of SV-1 than did primary tumors, but this difference was not statistically significant. Kaplan–Meier and Cox univariate survival analyses indicated an improved survival time in patients with high SV-1 compared with those with low GHRH-R expression, but this difference was not statistically significant. The immunohistochemical expression of SV-1 seems to be a favorable prognostic factor in CRC. |
| Databáze: | OpenAIRE |
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