Carotid Atherosclerotic Plaque Characteristics on Magnetic Resonance Imaging Relate With History of Stroke and Coronary Heart Disease

Autor: Aad van der Lugt, Jolanda J. Wentzel, Quirijn J.A. van den Bouwhuijsen, M. Arfan Ikram, Marileen L.P. Portegies, Meike W. Vernooij, Mariana Selwaness, Daniel Bos, Albert Hofman, Oscar H. Franco
Přispěvatelé: Epidemiology, Radiology & Nuclear Medicine, Neurology, Cardiology
Rok vydání: 2016
Předmět:
Carotid Artery Diseases
Male
medicine.medical_specialty
Population
Coronary Disease
030204 cardiovascular system & hematology
Asymptomatic
Carotid Intima-Media Thickness
Magnetic resonance angiography
Brain Ischemia
Brain ischemia
Cohort Studies
03 medical and health sciences
Rotterdam Study
0302 clinical medicine
Sex Factors
Risk Factors
Internal medicine
medicine
Humans
Carotid Stenosis
cardiovascular diseases
Prospective Studies
education
Stroke
Aged
Netherlands
Advanced and Specialized Nursing
Aged
80 and over
education.field_of_study
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Plaque
Atherosclerotic
Stenosis
Carotid Arteries
Cardiology
Female
Neurology (clinical)
Radiology
medicine.symptom
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Magnetic Resonance Angiography
Zdroj: Stroke, 47(6), 1542-U333. Lippincott Williams & Wilkins
ISSN: 1524-4628
0039-2499
Popis: Background and Purpose— Because atherosclerosis is a systemic disease, presence and composition on 1 location may relate to ischemic events in distant locations. We examined whether carotid atherosclerotic wall thickness, stenosis, and plaque composition are related to history of ischemic stroke and coronary heart disease (CHD). Methods— From the population-based Rotterdam Study, 1731 asymptomatic participants (mean age, 72.4±9.1 years; 55% males) underwent magnetic resonance imaging of both carotid arteries. We assessed carotid wall thickness, stenosis and plaque composition, that is presence of intraplaque hemorrhage, lipid, and calcification. History of ischemic stroke and CHD was assessed until date of magnetic resonance imaging. The study was approved by the institutional review board, and all participants gave informed consent. Logistic regression analyses adjusted for age and traditional cardiovascular risk factors were used to study sex-specific associations between plaque characteristics and clinical events. Results— We found that both carotid stenosis and intraplaque hemorrhage were associated with ischemic stroke in men but not in women (men: odds ratio [OR] for stenosis [per 10% increase]: 1.17 [95% CI, 1.06–1.30] and for intraplaque hemorrhage 2.39 [95% CI, 1.32–4.35]). In both men and women, carotid stenosis was associated with CHD (men: OR per 10% increase 1.12 [95% CI, 1.04–1.21] and women: OR, 1.17 [95% CI, 1.03–1.34]) and carotid wall thickness was associated with CHD (men: OR, 1.20 [95% CI, 1.03–1.39] and women: OR, 1.21 [95% CI, 0.88–1.65]). None of the plaque components was associated with CHD. Conclusions— Whereas carotid plaque thickness and stenosis are associated with the history of ischemic stroke and CHD, carotid intraplaque hemorrhage is associated with ischemic stroke, but not with CHD, providing novel insights into the pathogenesis of cardiovascular events.
Databáze: OpenAIRE
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