Structure-activity studies of RNA-binding oxazolidinone derivatives
| Autor: | Shu Zhou, Iwona Maciagiewicz, Jennifer V. Hines, Stephen C. Bergmeier |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Riboswitch
Chemistry Hydrogen bond Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science RNA Biochemistry Article Structure-Activity Relationship Förster resonance energy transfer Drug Discovery Fluorescence Resonance Energy Transfer Molecular Medicine Structure–activity relationship Nucleic Acid Conformation Molecular Biology Quantitative analysis (chemistry) Oxazolidinones |
| Zdroj: | Bioorganicmedicinal chemistry letters. 21(15) |
| ISSN: | 1464-3405 |
| Popis: | The structure–activity relationship of a series of oxazolidinones binding to T-box riboswitch antiterminator RNA has been investigated. Oxazolidinones differentially substituted at C-5 were prepared and the ligand-induced fluorescence resonance energy transfer (FRET) changes in FRET-labeled antiterminator model RNA were assayed. Both qualitative and quantitative analysis of the structure–activity relationship indicate that hydrogen bonding and hydrophobic properties play a significant role in ligand binding. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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