Management of mixed acute rejection driven by a de novo donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T-cells in a kidney recipient: a case report
| Autor: | A Rodríguez-Campón, G Tabernero, P Fraile, Francisco Boix, María C. Chillón, Ramón García-Sanz, S García-Sánchez, J Feito |
|---|---|
| Přispěvatelé: | Junta de Castilla y León |
| Rok vydání: | 2021 |
| Předmět: |
Donor specific antibodies
Microbiology (medical) T-cell mediated rejection Transplant recipient Clinical Biochemistry Immunology Desensitization Human leukocyte antigen Microbiology 03 medical and health sciences 0302 clinical medicine Rescue therapy medicine Immunology and Allergy Cytotoxic T cell Mixed acute rejection 0303 health sciences Kidney biology medicine.diagnostic_test 030306 microbiology business.industry Biochemistry (medical) HLA surgical procedures operative Infectious Diseases medicine.anatomical_structure Antibody-mediated rejection 030220 oncology & carcinogenesis biology.protein Complement binding Renal biopsy Antibody business CD8 |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0967-4845 |
| DOI: | 10.1080/09674845.2021.1927308 |
| Popis: | Mixed acute rejection is a clinicopathological entity that is difficult to accurately diagnose, and so may be under-reported. Allografts are lost more often than in either humoral or cellular rejection. The diagnosis requires both histological and immunological studies on renal biopsy and blood specimens from the transplant recipient to provide the required rescue therapy to abolish the allogeneic response against the graft. We present a clinical case report of an active mixed acute rejection driven by a de novo donor-specific complement-binding anti-DQB1*03:01 antibody and intraepithelial CD8 T-cells in a patient with a kidney transplant. The patient was diagnosed, treated, and followed up as per the local institution’s procedure with a full recovery of graft function. Our case emphasises the challenge of a mixed acute rejection and supports the need to improve the post-transplant outcome of recipients and their grafts. This work was partially funded by the Gerencia Regional de Salud (GRS) of Castilla y León [GRS 2080/A/19]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|