Construction of block copolymers for the coordinated delivery of doxorubicin and magnetite nanocubes

Autor: Jiang Jiang, Nandanan Erathodiyil, Shujun Gao, Jackie Y. Ying, Nor Lizawati Ibrahim, Yong Wang
Rok vydání: 2013
Předmět:
Zdroj: Journal of Controlled Release. 169:211-219
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2013.02.024
Popis: Multifunctional nanoparticles combine drug and imaging agent together to assign both therapeutic and diagnostic functions. However, particle aggregation/dissociation and/or major differences in the bio-distribution and targeting capability of drugs and imaging probes are main obstacles for the efficient, coordinated delivery of multiple agents, unless the different agents can be tightly bound and well-protected during their circulation in vivo . In this paper, we report the coordinated in vivo delivery of anti-cancer drugs and imaging agents by chemically loading doxorubicin and magnetite nanocubes (MNs) in the core of polymeric nanoparticles. Living polymerization, nitroxide-mediated radical polymerization (NMP), was applied to construct the optimal polymers to co-deliver doxorubicin and MNs. The resulting diblock polymers consisted of one block with triethylene glycol brushes and another block with carboxylic acid groups to bind doxorubicin and Fe 3 O 4 MNs. The optimal polymer has narrow polydispersity (PDI = 1.2) and high doxorubicin/MN loading (30 wt.%/28 wt.%). Core–shell particles were obtained with good stability and a suitable particle size of ~ 100 nm. The doxorubicin and MNs loaded in this polymeric system showed highly coordinated bio-distribution in the balb/C mice model. This system may have important impact on the design of effective and stable dual-agent co-delivery systems.
Databáze: OpenAIRE
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