CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma
| Autor: | Babatunji W Ogunkolade, Shihong Mao, Christopher A. Pieri, Johan Aarum, Jaroslaw Szary, Stephen A. Krawetz, Tania A. Jones, Diego Ottaviani, Muhammad A. Mumin, Elliott Lever, Denise Sheer, Rossitza Christova |
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| Rok vydání: | 2012 |
| Předmět: |
Genetics
CCCTC-Binding Factor Binding Sites CD74 biology chemical and pharmacologic phenomena Gene Regulation Chromatin and Epigenetics Matrix Attachment Regions Major histocompatibility complex Acquired immune system Chromatin MHC Class II Gene Major Histocompatibility Complex Repressor Proteins Interferon-gamma CTCF MHC class I biology.protein CIITA Humans Cells Cultured Transcription Factors |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/gks158 |
| Popis: | Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN-γ) is a fundamental step in the adaptive immune response to pathogens. Here, we show that reorganization of chromatin loop domains in the MHC is evident within the first 30 min of IFN-γ treatment of fibroblasts, and that further dynamic alterations occur up to 6 h. These very rapid changes occur at genomic sites which are occupied by CTCF and are close to IFN-γ-inducible MHC genes. Early responses to IFN-γ are thus initiated independently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent induction of transcription. |
| Databáze: | OpenAIRE |
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