Quantitative Histomorphometry of the Healthy Peritoneum
| Autor: | Betti Schaefer, Vedat Schwenger, Stefan Holland-Cunz, Claus Peter Schmitt, Uwe Querfeld, Viktoria A. Pfeifle, Dorothea Burkhardt, Joanne Nyarangi-Dix, Markus Wallwiener, Franz Schaefer, Stephan Macher-Goeppinger, Maria Bartosova, Bernd Lahrmann, Elke Wühl, Peter Sallay, Akos Ujszaszi |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Adolescent medicine.medical_treatment Peritoneal dialysis 030232 urology & nephrology Inflammation Biology 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit Article Epithelium Young Adult 03 medical and health sciences 0302 clinical medicine Peritoneum medicine Lymphatic vessel Humans Child Lymphatic Vessels Membrane Glycoproteins Multidisciplinary Infant Anatomy Middle Aged 030104 developmental biology Lymphatic system medicine.anatomical_structure Child Preschool Female medicine.symptom Mesothelial Cell Blood vessel |
| Zdroj: | Scientific Reports |
| Popis: | The peritoneum plays an essential role in preventing abdominal frictions and adhesions and can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal and 69 omental specimens were obtained from 107 patients (0.1–60 years) undergoing surgery for disease not affecting the peritoneum for automated quantitative histomorphometry and immunohistochemistry. The mesothelial cell layer morphology and protein expression pattern is similar across all age groups. Infants below one year have a thinner submesothelium; inflammation, profibrotic activity and mesothelial cell translocation is largely absent in all age groups. Peritoneal blood capillaries, lymphatics and nerve fibers locate in three distinct submesothelial layers. Blood vessel density and endothelial surface area follow a U-shaped curve with highest values in infants below one year and lowest values in children aged 7–12 years. Lymphatic vessel density is much lower and again highest in infants. Omental blood capillary density correlates with parietal peritoneal findings, whereas only few lymphatic vessels are present. The healthy peritoneum exhibits major thus far unknown particularities, pertaining to functionally relevant structures and subject to substantial changes with age. The reference ranges established here provide a framework for future histomorphometric analyses and peritoneal transport modeling approaches. |
| Databáze: | OpenAIRE |
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