Clear Cell Carcinoma Arising in Endometriosis of the Rectum Following Progestin Therapy
| Autor: | W. Ulrich, C. Peters-Engl, H. Mühlbauer, W. Pokieser, M. Kisser, R. Schmerker |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Endometriosis Rectum Constriction Pathologic Medroxyprogesterone Acetate Pathology and Forensic Medicine Malignant transformation Fatal Outcome Carcinoma Humans Medicine Medroxyprogesterone acetate Radical surgery Gynecology Progesterone Congeners Rectal Neoplasms business.industry Cell Biology Periodic Acid-Schiff Reaction medicine.disease medicine.anatomical_structure Clear cell carcinoma Adenocarcinoma Female Radiology business Adenocarcinoma Clear Cell medicine.drug |
| Zdroj: | Pathology - Research and Practice. 198:121-124 |
| ISSN: | 0344-0338 |
| DOI: | 10.1078/0344-0338-00198 |
| Popis: | A 40-year-old woman presented at our hospital with rectal stenosis. Computed tomography demonstrated a conglomerate tumor in the pelvis and malignant look-alike lesions in the liver and in both lungs. A palliative deep rectum resection was done. Histologically, clear cell carcinoma with a small area of endometrioid carcinoma was diagnosed. Severe endometriosis had been diagnosed 13 years earlier. The patient had been treated with medroxyprogesterone acetate (MPA) for two years; no estrogen therapy had been given. The association between unopposed estrogen replacement therapy and malignant transformation of endometriosis is documented, but malignant transformation following progestin therapy has not been reported previously. It appears that radical surgery is the only means of preventing malignant transformation of the lesion in patients with endometriosis. |
| Databáze: | OpenAIRE |
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