Sarcoidosis-lymphoma syndrome with portal hypertension: diagnostic clues and approach
| Autor: | Kai Mizobuchi, Tadashi Yoshino, Kazumasa Nanjo, Nobuyuki Tanida, Miki Mizobuchi, Hiromichi Yamai, Kenji Yorita, Satoshi Ito, Niranjan Sharma, Shigeto Shimizu, Koji Ueta, Kazuhisa Onishi, Hisashi Matsuoka, Fumio Chikamori, Jun Iwabu, Sawaka Yukishige, Norihiro Hokimoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Liver tumor PET/CT medicine.medical_treatment Splenectomy R895-920 Hepatosplenomegaly Case Report 030218 nuclear medicine & medical imaging Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Biopsy medicine Laparoscopic liver biopsy Radiology Nuclear Medicine and imaging Sarcoidosis-lymphoma syndrome Portal hypertension PET-CT medicine.diagnostic_test business.industry medicine.disease Lymphoma Primary hepatic Hodgkin lymphoma Hepatic sarcoidosis Sarcoidosis medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Radiology Case Reports Radiology Case Reports, Vol 16, Iss 8, Pp 2192-2201 (2021) |
| ISSN: | 1930-0433 |
| Popis: | Sarcoidosis-lymphoma syndrome associated with portal hypertension is very rare. A 68-year-old female presented with a 5 kg weight loss in 6 months. Soluble interleukin-2 receptor activity was increased and total platelet count was decreased. Contrast-enhanced computed tomography showed the presence of hepatosplenomegaly and a 3 cm-sized tumor in segment 3 of the liver. The hepatic venous catheterization showed mild portal hypertension. On fluorodeoxyglucose-positron emission tomography/computed tomography, progressive malignant lymphoma was suspected. However, bone marrow biopsy showed multiple noncaseating granulomas. A laparoscopic liver biopsy revealed that the liver tumor had features of Hodgkin lymphoma. There were multiple noncaseating epithelioid granulomas in the portal tracts of the liver. Splenectomy for splenomegaly and partial hepatectomy for the liver tumor were performed. Pathological examination of the resected specimens revealed multiple noncaseating epithelioid granulomas in the liver and spleen. Histopathology of th e liver tumor confirmed classic Hodgkin lymphoma with mixed cellularity. We conclude that hepatic venous catheterization, positron emission tomography/computed tomography, and pathological examinations of bone marrow, liver, and spleen are crucial for the diagnosis of sarcoidosis-lymphoma syndrome associated with portal hypertension. |
| Databáze: | OpenAIRE |
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