An 8-year follow-up study of pulmonary function in patients with rheumatoid arthritis
| Autor: | P. Oxholm, C. S. Ulrik, N. J. Kriegbaum, M. Linstow, V. Backer |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Vital Capacity Immunology Pulmonary function testing Arthritis Rheumatoid Rheumatology DLCO Forced Expiratory Volume Diffusing capacity Internal medicine medicine Humans Immunology and Allergy Aged Aged 80 and over Lung business.industry Pulmonary Diffusing Capacity Respiratory disease Middle Aged respiratory system Prognosis medicine.disease Respiratory Function Tests Surgery Cross-Sectional Studies medicine.anatomical_structure Rheumatoid arthritis Cardiology Female business Follow-Up Studies |
| Zdroj: | Rheumatology International. 14:115-118 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/bf00300812 |
| Popis: | To evaluate longitudinal alterations in pulmonary function, 63 patients suffering from rheumatoid arthritis (RA) with previously reported reduced pulmonary diffusing capacity were re-examined in an 8-year follow-up study. Cross-sectional examination revealed normal values for vital capacity (VC), forced expiratory volume in 1 s (FEV1) and diffusing capacity per litre alveolar volume (KCO). Total diffusing capacity (DLCO; P>0.0001), maximal expiratory flow at 75% of expired VC (MEF 75; P>0.0001) and MEF 50 (P>0.01) were decreased. Longitudinal evaluation revealed unchanged MEF50, MEF75 and FEV1, whereas increases in DLCO (P>0.0001) and KCO (P>0.0001) and a decrease in VC (P>0.05) were found. The longitudinal changes in diffusing capacity were unrelated to patient age, disease duration, disease activity in the study period or pulmonary function at the first examination. Thus, in patients suffering from RA, the most prominent functional pulmonary abnormality, decreased diffusing capacity, appeared to improve in the course of time, despite a slight decrease in VC and continued articular disease activity. |
| Databáze: | OpenAIRE |
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