Prognostic significance of cystic lymph nodal metastasis in nasopharyngeal carcinoma
| Autor: | Jeremy Chee, Eric Ting, Chwee Ming Lim, Chih Ching Choong, Yohanes Ting, Tze Choong Charn, Kwok Seng Loh |
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| Rok vydání: | 2016 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty China Kaplan-Meier Estimate Risk Assessment Disease-Free Survival Cohort Studies 03 medical and health sciences 0302 clinical medicine Nodal status Internal medicine Cause of Death medicine Overall survival Humans In patient Neoplasm Invasiveness 030223 otorhinolaryngology Aged Neoplasm Staging Retrospective Studies Analysis of Variance Nasopharyngeal Carcinoma business.industry Nodal metastasis Head and neck cancer Carcinoma Nasopharyngeal Neoplasms Middle Aged medicine.disease Magnetic Resonance Imaging Survival Analysis Increased risk Otorhinolaryngology Nasopharyngeal carcinoma 030220 oncology & carcinogenesis Lymphatic Metastasis Multivariate Analysis Female Lymph Lymph Nodes business Tomography X-Ray Computed |
| Zdroj: | Headneck. 39(9) |
| ISSN: | 1097-0347 |
| Popis: | Background The purpose of this study was to determine the prevalence of cystic lymph nodal metastasis (CLNM) and its prognostic value in patients with nasopharyngeal carcinoma (NPC). Methods A retrospective review was conducted on 257 patients with NPC, analyzing the presence of CLNM on MRI or CT scans. Oncologic outcomes were performed using the Kaplan-Meier analysis. Results One hundred eleven patients (43.2%) had CLNM at diagnosis. Overall, patients with CLNM had a poorer disease-specific survival (DSS; P < .001) and overall survival (OS; P < .001) compared with patients without CLNM. When analyzed according to nodal status, CLNM was associated with a higher rate of distant metastasis recurrence (P = .007), a poorer DSS (P < .001), and a poorer OS (P < .001) among patients with N2 disease. Conclusion The prevalence of CLNM was 43.2%. In patients with N2 disease, the presence of CLNM was significantly associated with a poorer DSS, OS, and increased risk of distant metastasis recurrence. |
| Databáze: | OpenAIRE |
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