Nanoescapology: progress toward understanding the endosomal escape of polymeric nanoparticles
| Autor: | Angus P. R. Johnston, Laura I. Selby, Christina Cortez-Jugo, Georgina K. Such |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Endosome Polymers media_common.quotation_subject Biomedical Engineering Human immunodeficiency virus (HIV) Medicine (miscellaneous) Bioengineering Nanotechnology 02 engineering and technology Endosomes Gene delivery medicine.disease_cause Silica nanoparticles Lysosomal compartment 03 medical and health sciences Drug Delivery Systems medicine Humans Internalization media_common business.industry Cytosolic delivery 021001 nanoscience & nanotechnology Polymeric nanoparticles 030104 developmental biology Nanoparticles 0210 nano-technology business |
| Zdroj: | Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 9(5) |
| ISSN: | 1939-0041 |
| Popis: | Using nanoparticles to deliver drugs to cells has the potential to revolutionize the treatment of many diseases, including HIV, cancer, and diabetes. One of the major challenges facing this field is controlling where the drug is trafficked once the nanoparticle is taken up into the cell. In particular, if drugs remain localized in an endosomal or lysosomal compartment, the therapeutic can be rendered completely ineffective. To ensure the design of more effective delivery systems we must first develop a better understanding of how nanoparticles and their cargo are trafficked inside cells. This needs to be combined with an understanding of what characteristics are required for nanoparticles to achieve endosomal escape, along with methods to detect endosomal escape effectively. This review is focused into three sections: first, an introduction to the mechanisms governing internalization and trafficking in cells, second, a discussion of methods to detect endosomal escape, and finally, recent advances in controlling endosomal escape from polymer- and lipid-based nanoparticles, with a focus on engineering materials to promote endosomal escape. WIREs Nanomed Nanobiotechnol 2017, 9:e1452. doi: 10.1002/wnan.1452 For further resources related to this article, please visit the WIREs website. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text