SARS-CoV-2 Interference of Influenza Virus Replication in Syrian Hamsters
| Autor: | Peter J Halfmann, Noriko Nakajima, Yuko Sato, Kenta Takahashi, Molly Accola, Shiho Chiba, Shufang Fan, Gabriele Neumann, William Rehrauer, Tadaki Suzuki, Yoshihiro Kawaoka |
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| Rok vydání: | 2021 |
| Předmět: |
Myxovirus Resistance Proteins
Mesocricetus Coinfection SARS-CoV-2 viruses Influenza A Virus H3N2 Subtype Brief Report virus diseases COVID-19 respiratory system Virus Replication antiviral respiratory tract diseases Infectious Diseases AcademicSubjects/MED00290 Cricetinae Immunology and Allergy Animals Humans MX1 skin and connective tissue diseases influenza |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 |
| Popis: | The effects of simultaneous or serial infections with SARS-CoV-2 and influenza virus are unknown. Here, we report that, in a hamster model, SARS-CoV-2 infection at the same time as or prior to H3N2 influenza virus infection resulted in significantly reduced influenza virus titers in the lungs and nasal turbinates of infected animals. This interference of influenza virus replication may correlate with SARS-CoV-2-induced expression of the antiviral gene MX1. |
| Databáze: | OpenAIRE |
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