Computed tomography findings after radiofrequency ablation in locally advanced pancreatic cancer

Autor: Tyche C. Derksen, Marieke S. Walma, Steffi J.E. Rombouts, Richard van Hillegersberg, Maarten S. van Leeuwen, Chung Y. Nio, I. Q. Molenaar, Hjalmar C. van Santvoort
Přispěvatelé: Radiology and Nuclear Medicine, CCA - Imaging and biomarkers, Other departments
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Radiofrequency ablation
Locally advanced pancreatic cancer
Postoperative Complications/diagnostic imaging
law.invention
Neoplasm Recurrence
Local/diagnostic imaging
0302 clinical medicine
Postoperative Complications
law
Occlusion
Medicine
Prospective Studies
Prospective cohort study
Tomography
Computed tomography
Imaging findings
Netherlands
Radiological and Ultrasound Technology
Gastroenterology
Middle Aged
Thrombosis
X-Ray Computed
medicine.anatomical_structure
surgical procedures
operative
Pancreatic Neoplasms/diagnostic imaging
Radiology Nuclear Medicine and imaging
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Female
Radiology
medicine.symptom
Pancreas
Ablation zone
medicine.medical_specialty
Local/diagnostic imaging
Urology
Asymptomatic
Article
03 medical and health sciences
Journal Article
Humans
Radiology
Nuclear Medicine and imaging
Superior mesenteric vein
Aged
Radiofrequency Ablation
business.industry
medicine.disease
Pancreatic Neoplasms
Neoplasm Recurrence
Feasibility Studies
Neoplasm Recurrence
Local
business
Tomography
X-Ray Computed
Zdroj: Abdominal Radiology, 43(10), 2702. Springer New York
Abdominal radiology (New York), 43(10), 2702-2711. Springer New York
Abdominal Radiology (New York)
ISSN: 2366-004X
2366-0058
Popis: Purpose The purpose of the study was to provide a systematic evaluation of the computed tomography(CT) findings after radiofrequency ablation (RFA) in locally advanced pancreatic cancer(LAPC). Methods Eighteen patients with intra-operative RFA-treated LAPC were included in a prospective case series. All CT-scans performed prior to RFA and 1 week and 3 months of post-RFA, according to standard regimen, were assessed by two radiologists in consensus, using standardized radiological scoring lists. Results 51 CT-scans were assessed. One week after RFA, the ablation zone was visible in all patients as a (partially) sharply defined (83%), heterogeneous area (94%). At 3 months of follow-up, the ablation zone was completely invaded by tumor in 67% of patients and still present, but decreased in 33%. In two patients (11%), local thrombosis and/or occlusion of the superior mesenteric vein occurred. The occlusions persisted without clinical consequences and the thrombosis disappeared. A peripancreatic fluid collection was visible 1 week after RFA in 3 patients, wherein the ablation zone extended ventrally outside of the pancreas. Conclusions Directly after RFA for LAPC, a well-defined ablation zone is visible on CT-imaging. This ablation zone is usually replaced by tumor ingrowth after 3 months. Moreover, the ablation zone regularly included vascular structures, with rare asymptomatic venous occlusion or thrombosis and without adverse effects on arteries. Electronic supplementary material The online version of this article (10.1007/s00261-018-1519-y) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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