Changes in pupil size and intraocular pressure after topical application of 0.5% tropicamide to the eyes of dogs sedated with butorphanol
| Autor: | Aure-Eline Grillot, Jean-Yves Douet, Faouzi Lyarzhri, Alain Regnier, Sophie Jugant |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Intraocular pressure Mydriatics genetic structures 040301 veterinary sciences Butorphanol Conscious Sedation 0403 veterinary science Random Allocation Tonometry Ocular Tropicamide Dogs Ophthalmology medicine Animals Intraocular Pressure Random allocation Cross-Over Studies General Veterinary business.industry 0402 animal and dairy science Pupil size Pupil 04 agricultural and veterinary sciences General Medicine 040201 dairy & animal science Crossover study eye diseases Tears Female sense organs Ophthalmic Solutions business medicine.drug |
| Zdroj: | American journal of veterinary research. 80(1) |
| ISSN: | 1943-5681 |
| Popis: | OBJECTIVE: To assess changes in pupil size and intraocular pressure (IOP) following topical application of a 0.5% tropicamide solution in the eyes of healthy butorphanol-sedated dogs. ANIMALS: 12 healthy adult Beagles. PROCEDURES: In a randomized crossover study consisting of 2 treatment periods with a 1-week washout between periods, dogs received an IM injection of butorphanol (0.2 mg/kg) or an equal volume of sterile saline (0.9% NaCl) solution. For each dog, 1 drop of 0.5% tropicamide ophthalmic solution was topically instilled in one eye and 1 drop of artificial tear solution was topically instilled in the other eye 10 minutes after the IM injection and again 5 minutes later. Extent of sedation, pupil size, and IOP were evaluated from 20 minutes before to 80 minutes after the IM injection and compared among treatment combinations. RESULTS: Butorphanol induced mild (n = 9) or moderate (3) sedation in all dogs and slightly delayed the onset of, but did not prevent, tropicamide-induced mydriasis. Butorphanol caused a significant increase in IOP, which was not exacerbated by tropicamide-induced mydriasis; however, that increase was generally not sufficient to exceed the upper limit of the IOP reference range. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that butorphanol did not prevent tropicamide-induced mydriasis but did increase the IOP in ophthalmologically normal Beagles. Although the butorphanol-induced increase in IOP did not appear clinically relevant for the dogs of this study, that may not be true for dogs with glaucoma, and care should be taken when butorphanol is administered to such dogs. |
| Databáze: | OpenAIRE |
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