Doxorubicin‐loaded polyphosphate glass microspheres for transarterial chemoembolization
| Autor: | Mark Filiaggi, Arash Momeni, Daniel M. Chevrier, Catherine A. Whitman, Hayden P. Nix |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Cell Survival Biomedical Engineering 030218 nuclear medicine & medical imaging Lethal Dose 50 Biomaterials 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Polyphosphates Tumor Microenvironment medicine Humans Doxorubicin Chemoembolization Therapeutic Particle Size Antibiotics Antineoplastic Coacervate Polyphosphate fungi Biological activity Hep G2 Cells Hydrogen-Ion Concentration Microspheres In vitro Glass microsphere Drug Liberation chemistry 030220 oncology & carcinogenesis Drug delivery Emulsion Emulsions Glass Nuclear chemistry medicine.drug |
| Zdroj: | Journal of Biomedical Materials Research Part B: Applied Biomaterials. 108:2621-2632 |
| ISSN: | 1552-4981 1552-4973 |
| DOI: | 10.1002/jbm.b.34594 |
| Popis: | The standard of care for intermediate stage hepatocellular carcinoma is transarterial chemoembolization (TACE). Drug-eluting bead TACE (DEB-TACE) has emerged as a leading form of TACE, as it uses highly calibrated microspheres to deliver consistent embolization and controlled drug release to the tumor microenvironment. We report here on doxorubicin (DOX)-loaded polyphosphate glass microspheres (PGM) as a novel resorbable, radiopaque, preloaded DEB-TACE platform. Coacervate composed of polyphosphate chains complexed with Ba2+ , Ca2+ , and Cu2+ can be loaded with DOX prior to PGM synthesis, with PGM production achieved using a water-in-oil emulsion technique at room temperature yielding highly spherical particles in clinically relevant size fractions. In vitro, DOX release was found to be linear, pH dependent, and in accordance with Type II non-Fickian transport. PGM degradation was characterized by an initial burst release of degradation products over 7 days, followed by a plateau in mass loss at approximately 75% over a period of several weeks. in vitro studies indicate that PGM degradation products, namely Cu2+ , are cytotoxic and may interact with eluted DOX to impair its pharmacological activity. With additional compositional considerations, this approach may prove promising for DEB-TACE applications. |
| Databáze: | OpenAIRE |
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