Comparative in vivo pharmacokinetics study of affeic acid, isoferulic acid and ferulic acid in crude and three different prepared Cimicifuga foetida L
Autor: | Yongjun Cao, Lingtian Min, Yu Wu, Daguo Mi, Aihua Yang, Yan Xu, Zhengying Hua, Shuijie Shen, Weidong Li |
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Rok vydání: | 2020 |
Předmět: |
Male
Cimicifuga Clinical Biochemistry Tandem mass spectrometry 030226 pharmacology & pharmacy 01 natural sciences Biochemistry Sensitivity and Specificity Analytical Chemistry Ferulic acid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics Tandem Mass Spectrometry Drug Discovery Caffeic acid Cimicifuga foetida Animals Molecular Biology Chromatography High Pressure Liquid Pharmacology Chromatography 010401 analytical chemistry Area under the curve food and beverages Reproducibility of Results General Medicine Phenolic acid 0104 chemical sciences Isoferulic acid Rats chemistry Cinnamates Linear Models Drugs Chinese Herbal |
Zdroj: | Biomedical chromatography : BMCREFERENCES. 34(9) |
ISSN: | 1099-0801 |
Popis: | Our study investigated the differences in pharmacokinetics of three major components of crude Cimicifuga foetida L. and its fried product and honey- and liquor-prepared products. A rapid and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry approach was established for determing caffeic acid, isoferulic acid and ferulic acid in rat plasma. The approach has good linearity, precision, accuracy, recovery and stability. Phenolic acid was rapidly absorbed. The times to peak concentration were shorter in the processed group than those for the crude product, with their values of |
Databáze: | OpenAIRE |
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