Comparative in vivo pharmacokinetics study of affeic acid, isoferulic acid and ferulic acid in crude and three different prepared Cimicifuga foetida L

Autor: Yongjun Cao, Lingtian Min, Yu Wu, Daguo Mi, Aihua Yang, Yan Xu, Zhengying Hua, Shuijie Shen, Weidong Li
Rok vydání: 2020
Předmět:
Zdroj: Biomedical chromatography : BMCREFERENCES. 34(9)
ISSN: 1099-0801
Popis: Our study investigated the differences in pharmacokinetics of three major components of crude Cimicifuga foetida L. and its fried product and honey- and liquor-prepared products. A rapid and sensitive ultra-high performance liquid chromatography with tandem mass spectrometry approach was established for determing caffeic acid, isoferulic acid and ferulic acid in rat plasma. The approach has good linearity, precision, accuracy, recovery and stability. Phenolic acid was rapidly absorbed. The times to peak concentration were shorter in the processed group than those for the crude product, with their values of
Databáze: OpenAIRE
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