Ventilator-induced lung-injury in mouse models: Is there a trap?
| Autor: | Jennifer A. Kricker, Jon Petur Joelsson, Sigurbergur Karason, Saevar Ingthorsson, Thorarinn Gudjonsson |
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| Rok vydání: | 2021 |
| Předmět: |
Ventilator-induced lung injury
Mechanical ventilation Medicine (General) medicine.medical_specialty QH301-705.5 business.industry Critically ill medicine.medical_treatment Review General Medicine respiratory system Lung injury Animal models respiratory tract diseases R5-920 Mouse studies Acute injury Acute lung injury Breathing Medicine Biology (General) business Lung tissue Intensive care medicine |
| Zdroj: | Laboratory Animal Research Laboratory Animal Research, Vol 37, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2233-7660 |
| Popis: | Ventilator-induced lung injury (VILI) is a serious acute injury to the lung tissue that can develop during mechanical ventilation of patients. Due to the mechanical strain of ventilation, damage can occur in the bronchiolar and alveolar epithelium resulting in a cascade of events that may be fatal to the patients. Patients requiring mechanical ventilation are often critically ill, which limits the possibility of obtaining patient samples, making VILI research challenging. In vitro models are very important for VILI research, but the complexity of the cellular interactions in multi-organ animals, necessitates in vivo studies where the mouse model is a common choice. However, the settings and duration of ventilation used to create VILI in mice vary greatly, causing uncertainty in interpretation and comparison of results. This review examines approaches to induce VILI in mouse models for the last 10 years, to our best knowledge, summarizing methods and key parameters presented across the studies. The results imply that a more standardized approach is warranted. Supplementary Information The online version contains supplementary material available at 10.1186/s42826-021-00108-x. |
| Databáze: | OpenAIRE |
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