High Incidence of Factor V Leiden and Prothrombin G20210A in Healthy Southern Italians
| Autor: | Vincenzo Oriana, Gianluca Sottilotta, Corrado Mammì, Giuseppe Furlò, Vincenzo Trapani Lombardo, Caterina Latella |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Heterozygote Polymorphism Genetic High prevalence business.industry Homozygote Factor V Hematology General Medicine Thrombophilia medicine.disease White People Gene Frequency Italy Reference Values Factor V Leiden Humans Medicine Prothrombin G20210A Female Prothrombin High incidence business Demography |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis. 15:356-359 |
| ISSN: | 1938-2723 1076-0296 |
| Popis: | Factor V Leiden (FVL) and G20210 prothrombin (FII G20210A) mutations are risk factors for thromboembolism. In Europe, FVL is more prevalent in the north (7%) than in the south (3%), whereas FII G20210A is more common in the south (3% to 7%) than in the north (2% to 5%). In Italy, the prevalence is 2% to 3% for both. The aim of this study was to assess if these polymorphisms could be more frequent in the south than in the rest of Italy. In 105 blood donors in southern Italy, the prevalence of FVL and FIIG20210A was 9.5% and 5.7%, respectively. These prevalence data are higher when compared with published data. The results of this study are as high as those observed in Greece and the Middle East. The diffusion of FVL and FII G20210A in the Mediterranean, consequent to Phoenician and Greek colonization, could be a reason for the high prevalence observed. |
| Databáze: | OpenAIRE |
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