Prospects in NSAID-derived chemoprevention of colorectal cancer
| Autor: | SD Chell, Ann C. Williams, A-M H-Zadeh, Christos Paraskeva, David Qualtrough, Helena A. Patsos, Diane J. Hicks, IR Witherden, Abderrahmane Kaidi |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Colorectal cancer
medicine.medical_treatment Prostaglandin Mouse model of colorectal and intestinal cancer Pharmacology Biochemistry Models Biological chemistry.chemical_compound medicine Anticarcinogenic Agents Humans Receptors Prostaglandin E Cyclooxygenase Inhibitors Adverse effect Receptor Aspirin Preventive strategy business.industry Incidence Anti-Inflammatory Agents Non-Steroidal medicine.disease Receptors Prostaglandin E EP1 Subtype chemistry lipids (amino acids peptides and proteins) business Colorectal Neoplasms Prostaglandin E medicine.drug |
| Zdroj: | University of Bristol-PURE |
| ISSN: | 0300-5127 |
| Popis: | There is strong evidence for an important role for increased COX (cyclo-oxygenase)-2 expression and PG (prostaglandin) E2 production in colorectal tumorigenesis. PGE2 acts through four E-prostanoid receptors (EP1–4). COX-2 has therefore become a target for the potential chemoprevention and therapy of colorectal cancer. However, any therapeutic/preventive strategy has the potential to have an impact on physiological processes and hence result in side effects. General COX (COX-1 and -2) inhibition by traditional NSAIDs (non-steidal anti-inflammatory drugs), such as aspirin, although chemopreventive, has some side effects, as do some conventional COX-2-selective NSAIDs. As PGE2 is thought to be the major PG species responsible for promoting colorectal tumorigenesis, research is being directed to a number of protein targets downstream of COX-2 that might allow the selective inhibition of the tumour-promoting activities of PGE2, while minimizing the associated adverse events. The PGE synthases and E-prostanoid receptors (EP1–4) have therefore recently attracted considerable interest as potential novel targets for the prevention/therapy of colorectal cancer. Selective (and possibly combinatorial) inhibition of the synthesis and signalling of those PGs most highly associated with colorectal tumorigenesis may have some advantages over COX-2-selective inhibitors. |
| Databáze: | OpenAIRE |
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