Is IgG4-Related Disease a Cause of Xerostomia? A Cohort Study of 60 Patients
| Autor: | Gaëlle Guettrot-Imbert, M. Hermet, G. Le Guenno, I. Delèvaux, P. Déchelotte, M. André, O. Aumaître, Jean-Louis Kémény, A. Tridon, Martin Soubrier |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology lcsh:Diseases of the musculoskeletal system Article Subject Immunology Disease Gastroenterology stomatognathic system Rheumatology Internal medicine Sicca syndrome parasitic diseases Biopsy Medicine skin and connective tissue diseases integumentary system biology medicine.diagnostic_test business.industry fungi medicine.disease Dry mouth Clinical Study biology.protein IgG4-related disease lcsh:RC925-935 Antibody medicine.symptom business Immunostaining Cohort study |
| Zdroj: | International Journal of Rheumatology International Journal of Rheumatology, Vol 2012 (2012) |
| ISSN: | 1687-9279 1687-9260 |
| Popis: | Objective. Immunoglobulin-G4-(IgG4-) related disease (IgG4 RD) is a fibrosing process characterized by a significant infiltration of IgG4-secreting plasma cells. IgG4 RD can affect almost all organs including salivary glands. Whether IgG4 RD plays a role in the development of sicca syndrome and particularly dry mouth syndrome remains to be investigated.Methods. We conducted a monocentric cohort study for two years to search for IgG4 RD features in patients with dry mouth syndrome using immunostainings of labial salivary gland specimens with anti-IgG4 antibody.Results. Among 60 patients presenting with dry mouth syndrome who underwent labial salivary gland biopsy, 18 showed positive immunostaining with the anti-IgG4 antibody including 4 patients with typical systemic IgG4 RD. Five also fulfilled criteria for Sjögren's syndrome.Conclusion. These findings suggest that clinical forms of IgG4 RD salivary involvement without salivary swelling may occur. This salivary involvement is probably overlooked in everyday practice and could represent a mild form of IgG4 RD. |
| Databáze: | OpenAIRE |
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