Sulphinpyrazone in Cardiovascular Elderly Azotemic Patients: A Proposal of a ‘Guided’ Incremental Dose Schedule
| Autor: | E Palummeri, C Borghi, L Dacco, R Di Ruvo, M Passeri |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Renal function Kidney Function Tests Biochemistry Drug Administration Schedule Dose schedule medicine Humans Aged business.industry Maintenance dose Biochemistry (medical) Mean age Drug Tolerance Cell Biology General Medicine Sulfinpyrazone Surgery Open study Basal (medicine) Tolerability Cardiovascular Diseases Anesthesia Kidney Failure Chronic Female business medicine.drug |
| Zdroj: | Journal of International Medical Research. 12:271-276 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006058401200501 |
| Popis: | Renal tolerability of a guided incremental dose schedule of sulphinpyrazone was evaluated in an open study of 2-month duration, performed in twenty-one cardiovascular elderly azotemic patients (thirteen males, eight females; mean age: 79 years, S.D.: 7·3 years). Starting dosage was 200 mg per day; daily dosage was then increased, every 4 days, by 200 mg or kept constant for another 4 days, according to each patient's basal renal function, up to the maintenance dose: 800 mg/day. Eighty-one per cent of the patients followed a successful incremental pathway, 9% kept a constant daily dosage of 200 mg for 8 days, reaching then the maintenance daily dose without any problems. Nine per cent withdrew at 200 mg/day because renal function deteriorated at two consecutive visits. Renal function of the patients who completed the study significantly improved (two-way ANOVA, p < 0·01). General tolerability was good. The proposed incremental dose schedule of sulphinpyrazone can be successfully used in the treatment of cardiovascular elderly azotemic patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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