Asymmetric Dimethylarginine and Adiponectin After Renal Transplantation: Role of Obesity
| Autor: | Martin Haluzik, Jaroslav Racek, Otto Schück, Michal Kudla, Stefan Vitko, Vladimír Teplan, Romana Siroka |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Medicine (miscellaneous) Arginine Gastroenterology Body Mass Index Cohort Studies chemistry.chemical_compound Internal medicine medicine Humans Obesity Prospective Studies Risk factor Prospective cohort study Kidney transplantation Aged Kidney Nutrition and Dietetics Adiponectin business.industry Middle Aged medicine.disease Kidney Transplantation Transplantation Endocrinology medicine.anatomical_structure chemistry Nephrology Female business Asymmetric dimethylarginine Body mass index |
| Zdroj: | Journal of Renal Nutrition. 18:154-157 |
| ISSN: | 1051-2276 |
| DOI: | 10.1053/j.jrn.2007.10.030 |
| Popis: | In obese renal transplant recipients, we assessed the course of selected proinflammatory factors liable to influence long-term outcomes of transplant patients and kidney grafts.In a prospective cohort study, we examined a total of 140 renal transplant recipients for a period of 12 months. Based on body mass index (BMI), patients were divided into Group I (BMIor = 30 kg/m2, 68 patients) and Group II (BMIor = 30 kg/m2, 72 patients).Twelve months after renal transplantation, significant differences were found between Group I versus Group II in plasma levels of asymmetric dimethylarginine (ADMA) (3.65 [SD +/- 0.47 micromol/L] versus 2.01 [SD +/- 0.36 micromol/L], P.01), adiponectin (ADPN) (15.4 [SD +/- 6.6 microg/mL] versus 22.3 [SD +/- 8.2 microg/mL], P.01), leptin (51.3 [SD +/- 11.2 ng/L] versus 21.3 [SD +/- 9.2 ng/L], P.01), soluble leptin receptor (24.6 [SD +/- 8.4 U/mL] versus 46.1 [SD +/- 11.4 U/mL], P.01), resistin (20.8 [SD +/- 10.1 microg/mL] versus 14.6 [SD +/- 6.4 microg/mL], P.025), and triglycerides (3.9 [SD +/- 1.6] versus mmol/L 2.8 [SD +/- 1.6 mmol/L], P.01). There were significant correlations between ADMA and BMI (r = 0.520; P.001), and ADPN and BMI (r = -0.570, P.001). The correlation between ADMA and inulin clearance (Cin) was weak (r = -0.185, P.05).Obesity after renal transplantation is associated with increased ADMA and decreased ADPN in plasma, and this may represent a risk factor for renal transplant recipients. |
| Databáze: | OpenAIRE |
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