Cloning of peroxiredoxin, a novel antioxidant enzyme, from the helminth parasite Fasciola hepatica
| Autor: | Sharon McGonigle, John P. Dalton, G. P. Curley |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Antioxidant
medicine.medical_treatment Molecular Sequence Data Antioxidants Hepatica Complementary DNA medicine Animals Humans Fasciola hepatica Amino Acid Sequence Cloning Molecular Genes Helminth chemistry.chemical_classification Reactive oxygen species Base Sequence Sequence Homology Amino Acid biology Helminth Proteins Peroxiredoxins DNA Helminth biology.organism_classification Infectious Diseases Peroxidases Biochemistry chemistry Catalase biology.protein Cattle Animal Science and Zoology Parasitology Peroxiredoxin Peroxidase |
| Zdroj: | Parasitology. 115:101-104 |
| ISSN: | 1469-8161 0031-1820 |
| DOI: | 10.1017/s0031182097001170 |
| Popis: | A cDNA was isolated from a cDNA expression library using serum prepared against a high molecular mass fraction of Fasciola hepatica excretory–secretory products. The full-length cDNA encodes a member of the recently described peroxiredoxin antioxidant family. Peroxiredoxin could be the major hydrogen peroxide removing antioxidant in F. hepatica since this parasite does not express a catalase and expresses little glutathione peroxidase activity. This novel antioxidant may be involved in functions such as protection against reactive oxygen species (ROS) generated by metabolic processes and/or protection of the parasite against ROS released by immune effector cells. |
| Databáze: | OpenAIRE |
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