Visual Object Discrimination Impairment as an early predictor of Mild Cognitive Impairment and Alzheimer’s disease
| Autor: | Ailyn Penate, Monica Rosselli, Sara N. Burke, Rosie E. Curiel Cid, David A. Loewenstein, Meredith Wicklund, Russell M. Bauer, Leslie S. Gaynor |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Visual perception genetic structures Context (language use) Disease Audiology Neuropsychological Tests behavioral disciplines and activities Article Temporal lobe Discrimination Psychological Alzheimer Disease Perirhinal cortex medicine Dementia Humans Cognitive Dysfunction Aged business.industry General Neuroscience Neuropsychology Recognition Psychology medicine.disease Prognosis Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Pattern Recognition Visual Relative risk Female Neurology (clinical) Amnesia business |
| Popis: | Objective:Detection of cognitive impairment suggestive of risk for Alzheimer’s disease (AD) progression is crucial to the prevention of incipient dementia. This study was performed to determine if performance on a novel object discrimination task improved identification of earlier deficits in older adults at risk for AD.Method:In total, 135 participants from the 1Florida Alzheimer’s Disease Research Center [cognitively normal (CN), Pre-mild cognitive impairment (PreMCI), amnestic mild cognitive impairment (aMCI), and dementia] completed a test of object discrimination and traditional memory measures in the context of a larger neuropsychological and clinical evaluation.Results:The Object Recognition and Discrimination Task (ORDT) revealed significant differences between the PreMCI, aMCI, and dementia groups versus CN individuals. Moreover, relative risk of being classified as PreMCI rather than CN increased as an inverse function of ORDT score.Discussion:Overall, the obtained results suggest that a novel object discrimination task improves the detection of very early AD-related cognitive impairment, increasing the window for therapeutic intervention. (JINS, 2019,25, 688–698) |
| Databáze: | OpenAIRE |
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