High Molecular Weight Kininogen: A Review of the Structural Literature

Autor:	Michał Ponczek
Rok vydání:	2021
Předmět:	Kininogen High-Molecular-Weight QH301-705.5 kininogen Review AlphaFold Bradykinin Catalysis kinin Inorganic Chemistry Structure-Activity Relationship Animals Humans structure Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Spectroscopy Kininogens Cryoelectron Microscopy Organic Chemistry General Medicine proteins Computer Science Applications Chemistry cryo-EM Kallikreins circulatory and respiratory physiology
Zdroj:	International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 13370, p 13370 (2021)
ISSN:	1422-0067
Popis:	Kininogens are multidomain glycoproteins found in the blood of most vertebrates. High molecular weight kininogen demonstrate both carrier and co-factor activity as part of the intrinsic pathway of coagulation, leading to thrombin generation. Kininogens are the source of the vasoactive nonapeptide bradykinin. To date, attempts to crystallize kininogen have failed, and very little is known about the shape of kininogen at an atomic level. New advancements in the field of cryo-electron microscopy (cryoEM) have enabled researchers to crack the structure of proteins that has been refractory to traditional crystallography techniques. High molecular weight kininogen is a good candidate for structural investigation by cryoEM. The goal of this review is to summarize the findings of kininogen structural studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda6fe04647643e1eb34097baa1ebb3f https://doi.org/10.3390/ijms222413370 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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