INFLUENCE OF METOPROLOL SUCCINATE ON REGULATORY AND ADAPTIVE STATUS OF PATIENTS WITH CHRONIC HEART FAILURE FUNCTIONAL CLASS I. RESULTS OF NOT COMPARATIVE STUDY
| Autor: | S. G. Kanorskiy, V. G. Tregubov, V. M. Pokrovskiy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Blood level
medicine.medical_specialty metoprolol succinate medicine.drug_class Metoprolol Succinate RM1-950 сhronic heart failure Internal medicine medicine Natriuretic peptide Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) Blood pressure monitoring cardiovascular diseases Metoprolol business.industry VO2 max medicine.disease сardio-respiratory synchronism medicine.anatomical_structure Ventricle Heart failure Anesthesia RC666-701 Cardiology Therapeutics. Pharmacology Cardiology and Cardiovascular Medicine business regulatory and adaptive status medicine.drug |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 7, Iss 6, Pp 752-756 (2016) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Aim. To estimate metoprolol succinate effect on regulatory and adaptive status (RAS) of patients with сhronic heart failure (CHF) functional class (FC) I and arterial hypertension (HT) I-II stages. Material and methods. 51 patients with CHF FC I and HT I-II stage, (30 men and 21 women aged 52.6±1.4 yeas). Cardio-respiratory synchronism (CRS) test, 6-minute walking test, tread-mill burden test with registration of maximal oxygen consumption, 24-hour blood pressure monitoring, echocardiography and determination of N-terminal pro-brain natriuretic peptide (NT-proBNP) blood level were performed initially and after 6 months of therapy with metoprolol succinate (dose 78.1±5.7 mg/day) in sustained-release presentation. Results. Metoprolol succinate therapy had no significant effect on RAS (there was no unidirectional dynamics of the basic CRS test parameters: a range of synchronization decreased significantly from 8.8±0.4 to 7.2±0.6 сardio-respiratory cycles per minute (in 18%; р |
| Databáze: | OpenAIRE |
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