Malaria Vaccine Adjuvants: Latest Update and Challenges in Preclinical and Clinical Research
| Autor: | José Luis Pedraz, Rosa Maria Hernandez, Elena Mata, Aiala Salvador, Manoli Igartua |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Biomedical Research
Plasmodium falciparum Protozoan Proteins lcsh:Medicine Antigens Protozoan Review Article toll like receptors General Biochemistry Genetics and Molecular Biology Immune system Adjuvants Immunologic Antigen Malaria Vaccines medicine Humans prime boos immunization biogradable polymer microspheres General Immunology and Microbiology biology Malaria vaccine lcsh:R General Medicine enchancesprotective immunity biology.organism_classification medicine.disease falciparum circumsporozoite protein Malaria Vaccination Clinical research Immunization Immunology T-cell responses merozoite surface protein-1 inflamatory dendritic cells virus like particles acid sulfate esters |
| Zdroj: | BioMed Research International, Vol 2013 (2013) Addi. Archivo Digital para la Docencia y la Investigación instname BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | There is no malaria vaccine currently available, and the most advanced candidate has recently reported a modest 30% efficacy against clinical malaria. Although many efforts have been dedicated to achieve this goal, the research was mainly directed to identify antigenic targets. Nevertheless, the latest progresses on understanding how immune system works and the data recovered from vaccination studies have conferred to the vaccine formulation its deserved relevance. Additionally to the antigen nature, the manner in which it is presented (delivery adjuvants) as well as the immunostimulatory effect of the formulation components (immunostimulants) modulates the immune response elicited. Protective immunity against malaria requires the induction of humoral, antibody-dependent cellular inhibition (ADCI) and effector and memory cell responses. This review summarizes the status of adjuvants that have been or are being employed in the malaria vaccine development, focusing on the pharmaceutical and immunological aspects, as well as on their immunization outcomings at clinical and preclinical stages. This project was partially supported by the "Ministerio de Ciencia e Innovacion" (SAF2007-66115), the University of the Basque Country (UPV/EHU) (UFI 11/32), and FEDER funds. E. Mata thanks the Basque Government for a fellowship grant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|