A pilot placebo-controlled study of fluvoxamine for pathological gambling

Autor:	Carlos Blanco, Eva Petkova, Angela Ibañez, Jeronimo Saiz-Ruiz
Rok vydání:	2002
Předmět:	Adult Male Age Factors Pilot Projects General Medicine Disruptive Impulse Control and Conduct Disorders Psychiatry and Mental health Sex Factors Treatment Outcome Double-Blind Method Fluvoxamine Gambling Humans Female Selective Serotonin Reuptake Inhibitors
Zdroj:	Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. 14(1)
ISSN:	1040-1237
Popis:	The objective of this study was to evaluate the efficacy of fluvoxamine in the treatment of pathological gambling. Thirty-two patients were treated for 6 months in a double-blind, placebo-controlled study of fluvoxamine 200 mg/day. Outcome measures included reduction in money and time spent gambling per week. Longitudinal mixed effects models and completers analyses were used for estimation and hypothesis testing. Fluvoxamine was not statistically significantly different from placebo in the overall sample. However, fluvoxamine was statistically significantly superior to placebo in males and in younger patients. The power of the study was limited by the high (59%) placebo-response rate. Fluvoxamine may be a useful treatment for certain subgroups of patients with pathological gambling. Several methodological recommendations are made for future pharmacological trials of pathological gambling.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda070730a1a36ba24337301a7e25c5d https://pubmed.ncbi.nlm.nih.gov/12046642 Zobrazit plný text záznamu Full text from SpringerLink