Red cell free polyamine concentrations in patients on maintenance hemodialysis
| Autor: | V. Quemener, J.-Ph. Moulinoux, D. Chevet, P. Le Pogamp, V. Joyeux, M. Le Calvé |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Spermidine Urinary system medicine.medical_treatment Spermine General Biochemistry Genetics and Molecular Biology Excretion chemistry.chemical_compound Renal Dialysis Internal medicine Polyamines medicine Humans General Pharmacology Toxicology and Pharmaceutics Aged Uremia Red Cell General Medicine Middle Aged Endocrinology chemistry Biochemistry Putrescine Female Hemodialysis Polyamine |
| Zdroj: | Life Sciences. 29:955-962 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(81)90398-2 |
| Popis: | Changes in red cell polyamine levels were studied in 25 chronic renal failure patients on maintenance hemodialysis. The data showed : 1) that putrescine levels are extremely low and could not be quantitated by the method used ; 2) spermidine and spermine were seen to be present mainly in the form of free polyamines, since the protein precipitate contained only traces of bound polyamines ; 3) pre-dialysis spermidine levels were consistently elevated, whereas spermine levels were abnormally high in only a small proportion of the patients ; 4) in 20% of cases a hemodialysis session brought about a fall of over 30% in polyamine levels, particularly in spermidine ; 5) in 5 patients in whom subsequent determinations were performed 2 or 4 months later, both the pre-dialysis levels and the effects of hemodialysis on these levels were unpredictable and could not be correlated with any clinical factors. Since a fall in urinary polyamine excretion is probably a cause of polyamine accumulation in red cells, it is likely that the changes in serum free polyamine levels in chronic renal failure patients undergoing hemodialysis could contribute to changes in red cell free polyamine levels. |
| Databáze: | OpenAIRE |
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