Possible mechanism of action of perhexiline maleate on heart mitochondria
| Autor: | M. L. W. Kluppel, Annibal P. Campello, L.C Vieira Lopes, O. Silveira |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Oxaloacetates Ubiquinone Perhexiline Respiratory chain Oxidative phosphorylation Mitochondrion Reductase Pharmacology Biochemistry Malate dehydrogenase Oxidative Phosphorylation Electron Transport Oxygen Consumption Piperidines Malate Dehydrogenase medicine Animals NADH NADPH Oxidoreductases Aspartate Aminotransferases Chemistry Myocardium Mitochondria Muscle Rats Succinate Dehydrogenase Mechanism of action Perhexiline Maleate NAD+ kinase medicine.symptom |
| Zdroj: | Biochemical pharmacology. 25(21) |
| ISSN: | 0006-2952 |
| Popis: | Oxidative phosphorylation and oxidation of NAD+-linked substrates by rat heart mitochondria were depressed by 6.75 × 10−5 M perhexiline maleate (PM), while the succinate oxidation was increased to 320 per cent activity. The drug had no effect on mitochondrial succinic and malate dehydrogenase, NADH-ferricyanide reductase and NADH-CoQ reductase (340 nm); therefore, NADH-oxidase, mitochondrial electron-transporting particles (EP1), NADH-CoQ reductase (550 nm) and aspartate aminotransferase were inhibited. It is suggested that PM would act. preventing the reoxidation of NADH+ + H+ through the respiratory chain. |
| Databáze: | OpenAIRE |
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