Acute changes in lung function following controlled exposure to cookstove air pollution in the subclinical tests of volunteers exposed to smoke (STOVES) study
| Autor: | Rhiannon Shelton, John Mehaffy, John Volckens, Kristen M. Fedak, Tom Cole-Hunter, Nicholas Good, Gary J. Luckasen, Robert D. Brook, Ethan Walker, Maggie L. Clark, Christian L'Orange, Jennifer L. Peel, John R. Balmes, Ander Wilson, Robert B. Devlin |
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| Rok vydání: | 2020 |
| Předmět: |
Spirometry
Adult Health Toxicology and Mutagenesis Vital Capacity spirometry Air pollution Maximal Midexpiratory Flow Rate 010501 environmental sciences medicine.disease_cause Toxicology 01 natural sciences Article 03 medical and health sciences FEV1/FVC ratio Young Adult FEV1 0302 clinical medicine Environmental health Forced Expiratory Volume Smoke Medicine Humans 2.2 Factors relating to the physical environment Climate-Related Exposures and Conditions Indoor Cooking Aetiology Household Articles Lung Lung function 0105 earth and related environmental sciences Subclinical infection medicine.diagnostic_test business.industry Pharmacology and Pharmaceutical Sciences Health Effects of Household Energy Combustion FVC controlled exposure Health Effects of Indoor Air Pollution 030228 respiratory system Air Pollution Indoor Stove Respiratory cookstoves business |
| Zdroj: | Inhalation toxicology, vol 32, iss 3 Inhal Toxicol |
| Popis: | Background: Exposure to household air pollution generated as a result of cooking and heating is a leading contributor to global disease. The effects of cookstove-generated air pollution on adult lung function, however, remain uncertain. Objectives: We investigated acute responses in lung function following controlled exposures to cookstove-generated air pollution. Methods: We recruited 48 healthy adult volunteers to undergo six two-hour treatments: a filtered-air control and emissions from five different stoves with fine particulate matter (PM2.5) targets from 10 to 500 µg/m3. Spirometry was conducted prior to exposure and immediately, and three and 24 h post-exposure. Mixed-effect models were used to estimate differences in post-exposure lung function for stove treatments versus control. Results: Immediately post-exposure, lung function was lower compared to the control for the three highest PM2.5-level stoves. The largest differences were for the fan rocket stove (target 250 µg/m3; forced vital capacity (FVC): −60 mL, 95% confidence interval (95% CI) -135, 15; forced expiratory volume (FEV1): −51 mL, 95% CI -117, 16; mid-expiratory flow (FEF25–75): −116 mL/s, 95% CI -239, 8). At 3 h post-exposure, lung function was lower compared to the control for all stove treatments; effects were of similar magnitude for all stoves. At 24 h post-exposure, results were consistent with a null association for FVC and FEV1; FEF25–75 was lower relative to the control for the gasifier, fan rocket, and three stone fire. Conclusions: Patterns suggesting short-term decreases in lung function follow from exposure to cookstove air pollution even for stove exposures with low PM2.5 levels. |
| Databáze: | OpenAIRE |
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