Two New Cases of KIR3DP1, KIR2DL4-Negative Genotypes, One of which is also Lacking KIR3DL2
| Autor: | Ryszard Grendziak, Natalia Żuk, Anna Havrylyuk, Wanda Niepiekło-Miniewska, Wojciech Witkiewicz, David Senitzer, Valentyna Chopyak, Maciej Kurpisz, Joanna Dubis, Piotr Kuśnierczyk |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cytotoxicity
Immunologic Male Genotype Pseudogene Immunology Killer-cell immunoglobulin-like receptor Human leukocyte antigen Biology HLA-A3 Antigen KIR2DL4 Deletion Young Adult KIR2DL1 Receptors KIR Killer cell immunoglobulin-like receptor Immunology and Allergy Humans Receptor HLA-B27 Antigen Aged Genetics HLA-G Antigens Polymorphism Genetic HLA-A Antigens Receptors KIR3DL2 General Medicine Framework genes Killer Cells Natural Genetics Population CpG site KIR3DL2 Receptors KIR2DL4 Original Article Poland Ukraine Pseudogenes Protein Binding |
| Zdroj: | Archivum Immunologiae et Therapiae Experimentalis |
| ISSN: | 1661-4917 0004-069X |
| Popis: | The killer immunoglobulin-like receptor (KIR) genes KIR2DL4, KIR3DL2, and KIR3DP1 are present in virtually all humans. KIR2DL4 encodes a receptor present on uterine and decidual natural killer (NK) cells and some peripheral blood NK cells. Its only known ligand is the human leukocyte antigen-G molecule expressed on extravillous trophoblasts, and on tissues in some diseases. KIR3DL2 binds HLA-A*03 and HLA-A*11 as well as HLA-B*27 dimers, and microbial CpG DNA. KIR3DP1 is a pseudogene. During our immunogenetic studies we found two individuals, one from Lower Silesia district in Poland, and another from Western Ukraine, who were reproducibly negative for KIR2DL4 and KIR3DP1 genes, using three different PCR systems. Both individuals displayed very similar genotypes, possessing only KIR3DL3, KIR2DL3, KIR2DP1, KIR2DS1, and probably a rare variant of KIR2DL1. The Pole had also KIR3DL2, which the Ukrainian was apparently lacking. The Lower Silesia has been populated after the Second World War by a remarkable percentage with displaced people from Western Ukraine, which might contribute to genetic similarity of the two individuals described here. |
| Databáze: | OpenAIRE |
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